| Theme | Dialysis Therapy in Aging Society -- Current Status and Involved Problems | |
|---|---|---|
| Title | Essential points of pharmacotherapy for elderly dialysis patients | |
| Publish Date | 2007/07 | |
| Author | Sumio Hirata | Division of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kumamoto University |
| [ Summary ] | Elderly dialysis patients are frequently prescribed multiple drugs, because they have a variety of complications compared to the general elderly population. Hence, concerns arise as to drug interactions and a lack of compliance. In addition, elderly dialysis patients may be influenced by changes in drug distribution and drug metabolism. The incidence of adverse effects may also be high with high serum drug concentrations. A decrease in physiological functions with increasing age also affects pharmacotherapy for the elderly. For example, an increase in gastric pH causes a decrease in the phosphate binding ability of calcium carbonate, and decreased peristalsis in the colon causes deterioration, leading to constipation. Furthermore, the frequent administration of antimicrobial agents because of lowered immunity destroys their bacterial flora. Therefore, taking an appropriate laxative, or acidophilus in conjunction with dietary fiber is highly recommended. |
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