| Theme | Cytokines and Dialysis Treatment | |
|---|---|---|
| Title | Cytokine apheresis for multiple organ dysfunction syndrome | |
| Publish Date | 2007/04 | |
| Author | Yoshihiro Endo | Department of Surgery, Shiga University of Medical Science |
| Author | Takahisa Tabata | Department of Emergency and Intensive Care Medicine, Shiga University of Medical Science |
| Author | Tomoharu Shimizu | Department of Surgery, Shiga University of Medical Science |
| Author | Takao Saotome | Department of Emergency and Intensive Care Medicine, Shiga University of Medical Science |
| Author | Yutaka Eguchi | Department of Emergency and Intensive Care Medicine, Shiga University of Medical Science |
| Author | Tohru Tani | Department of Surgery, Shiga University of Medical Science |
| [ Summary ] | It is thought that multiple organ failure is caused by elevated cytokine levels. High absorption of cytokines can be one method to prevent multiple organ failure. Continuous hemodiafiltration (CHDF) has been used in an attempt to decrease cytokine levels. However, it has recently been found that CHDF has no positive effect in decreasing acute rises in cytokine levels. Direct hemoperfusion, using CTR-OO1 (Kaneka Co., Japan) is now being used to decrease cytokine levels. CTR-OO1 is modified Lixelle column, which is used in a β2 micro-globulin absorption column. In clinical trials, the hemodynamic parameters did not change during CTR-OO1 DHP in cases of pancreatitis. Cytokine levels did not increase with employment of CTR-OO1. However, cytokine levels increased when using CHDF. CTR-OO1 is also known to absorb bacterial structures. Because it can absorb both cytokines and bacterial structures, it has become one of the most important methods to treat septic infections. | |