The Japanese Journal of Clinical Dialysis Vol.23 No.10(1-1)

Theme Issues of Evidence-based Adequate Dialysis Therapy
Title Adequate hemodialysis and evidence : Dialysis dose and dialysis time
Publish Date 2007/09
Author Tadashi Tomo Second Department of Internal Medicine, Faculty of Medicine, Oita University
[ Summary ] Concerning the relationship of dialysis dosage to prognosis, it has been shown that an increase in dialysis dosage reduces the risk of morbidity in NCDS patients. It is also known that Kt/V is an additional factor related to mortality as seen in DOPPS. Additionally, an increase in Kt/V is associated with a reduction of risk factors for mortality. The above information was revealed in a statistical report by the JSDT (2002).
In relation to dialysis time, the correlation between shortening dialysis time and increases in mortality rates was reported in DOPPS. Furthermore, it was shown that shortened dialysis times elevated the relative risk of death. Conversely, improved outcomes for patients treated with HD for longer periods was reported.
To determine the most efficacious dialysis time, determination of optimum dialysis dosages is very important.
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