| Theme | New Drugs for Dialysis Patients | |
|---|---|---|
| Title | Pharmacokinetics in patients undergoing dialysis treatment | |
| Publish Date | 2006/06 | |
| Author | Satoshi Izumi | Department of Pharmacy Service, Shirasagi Hospital |
| [ Summary ] | Decreasing renal excretion of drugs is the most important pharmacokinetic parameter in patients undergoing dialysis therapy. Those drugs which are extensively excreted would be accumulated, if dialysis patients took them in the usual dosages. Therefore, since it may be easy to generate adverse reactions, appropriate dosage reduction or extension of dosage intervals is needed. Urinary excretion rates for parent drugs or active metabolites are the most important parameters for dosage adjustment in patients undergoing dialysis therapy. However, since the description of urinary excretion rates in package inserts often includes both the parent drugs and the metabolites, caution is necessary. Moreover, although changes in other pharmacokinetics parameters do not usually produce serious effects it is necessary to consider removal with dialysis and changes in protein binding rates of the drugs. |
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