| Theme | The Various Uremic Symptomes and their Causative Substances | |
|---|---|---|
| Title | Dyslipidemia in renal failure | |
| Publish Date | 2005/08 | |
| Author | Takahiro Ueno | Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine |
| [ Summary ] | It is well known that atherosclerotic diseases are major causes of mortality in patients with chronic renal failure (CRF). They are caused by numerous factors, defined as risk factors. One of these factors, dyslipidemia, is often observed in patients with CRF. The prominent features of uremic dyslipidemia are an increased levels of plasma triglycerides and a reduction in HDL cholesterol. On the other hand, CRF is associated with oxidative stress that promotes production of reactive oxygen species. In patients undergoing maintenance hemodialysis treatment, this condition is usually present with plasma carnitine insufficiency. This is due to accumulations of metabolic intermediates combined with impaired carnitine biosynthesis, reduced protein intake and increased removal via hemodialysis. Several studies have indicated that L-cartinine supplementation may be of some benefit in the prevention of atherosclerosis. For reduction of oxdative stress, high doseage supplementation with α-tocopherol also has been shown to reduce cardiovascular risk in studies of hemodialysis patients with preexisting cardiovascular disease. Moreover, it is essential to study the supposed mechanisms of uremic dyslipidemia, since optimal treatment is essential for the prevention or delay of cardiovascular complications in patients with CRF. |
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