The Japanese Journal of Clinical Dialysis Vol.21 No.9(11)

Theme The Various Uremic Symptomes and their Causative Substances
Title Skin disturbances in hemodialytic patients
Publish Date 2005/08
Author Akira Hattori Hattori Dermatology Clinic
[ Summary ] Skin lesions, including xerosis, pruritus, and hyperpigmentation, in hemodialysis patients are discussed Xerosis is caused by a change in the stratum corneum and the external structure of the skin. Pruritus can be triggered by C fibers though it is mainly caused by opioid peptides and opioid receptors. The Arrival of effective new treatments for this condition are expected in the future. As for hyperpigmentation, the frequency and severity of both are being improved. This may be a result of improvements in dialysis techniques. Elevations in the levels of serum β, γ-lipotropin have recently been considered to be a cause of hyperpigmentation in hemodialysis patients.
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