| Theme | Blood Pressure Control of Chronic Kidney Disease during Conservative Treatment, on Dialysis, and after Kidney Transplantation | |
|---|---|---|
| Title | Hypertension and chronic renal failure | |
| Publish Date | 2005/07 | |
| Author | Ken-ichi Miyoshi | The Second Department of Internal Medicine, Ehime University School of Medicine |
| Author | Takafumi Okura | The Second Department of Internal Medicine, Ehime University School of Medicine |
| Author | Jitsuo Higaki | The Second Department of Internal Medicine, Ehime University School of Medicine |
| [ Summary ] | Chronic renal failure causes high blood pressure because of sodium retention caused by the reduction of the glomerular capillary filtration coefficient and activation of the renin-angiotension-aldosterone and sympathetic nervous systems. Therefore, hypertension accompanying chronic renal failure is salt-sensitive. In addition, susceptibility to hypertensive renal injury is markedly increased in chronic renal failure. In normal kidneys, the capillary pressure in the glomeruli is kept relatively constant by the constriction of the precapillary sphincter, controlling the alternation of arterial pressure. This auto-regulation is impaired and high blood pressure is transmitted to the capillaries in the glomeruli without reduction in patients with chronic renal failure. For this reason, blood pressure control is essential for patients with chronic renal failure. | |