| Theme | New Modalities in Blood Purification Therapies | |
|---|---|---|
| Title | Hemofiltration with artificial tubules -- regeneration of filtrate | |
| Publish Date | 2005/02 | |
| Author | Akira Saito | Department of Molecular Medicine, Institute of Medical Science, Tokai University |
| [ Summary ] | An ultrafiltrate obtained at flow rates of 7 ml / min by continuous hemofiltration was introduced into a hollow fiber module, in which proximal tubular epithelial cells were grown on the inner surfaces. The filtrate water was actively transported to the patient's blood across the cell-attached hollow fiber membranes at the rate of 4 ml / min, 3 ml / min of the filtrate was discarded since the same amount would be replaced by drinking and meals. A bioartificial tubule device with a membrane area of 0.8 m2 can transport 6 l of water, sodium and glucose solution over 24 hours. A continuous hemofilter with a membrane area of 0.2-0.3 m2, which can receive filtrate from a patient at the rate of 7 ml / min, may be kept in a vest pocket. A double headed Watson-Marlow tube pump (WM-313), put in a lumber pouch or a back pack, can control the blood flow rate of 100 ml / min and a filtration rate of 7 ml / min at the same time. |
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