| Theme | Trace Elements in Dialysis Treatment | |
|---|---|---|
| Title | Selenium and myocardial disorders | |
| Publish Date | 2004/08 | |
| Author | Toru Suzuki | Department of Urology, School of Medicine, Iwate Medical University |
| Author | Karen Katoh | Department of Urology, School of Medicine, Iwate Medical University |
| Author | Tatsuru Nozawa | Department of Urology, School of Medicine, Iwate Medical University |
| Author | Fumihiko Hatafuku | Department of Urology, School of Medicine, Iwate Medical University |
| Author | Ryuichiro Konda | Department of Urology, School of Medicine, Iwate Medical University |
| Author | Tomoaki Fujioka | Department of Urology, School of Medicine, Iwate Medical University |
| [ Summary ] | Selenium, a constituent of glutathione peroxidase (GSHPx), plays a principal role in the protection of tissues from injury by free radicals. Previous studies have reported that a deficiency of selenium contributes to an increased incidence of cardiomyopathy and malignant tumors. Concentrations of serum selenium and GSHPx activity is significantly lower in hemodialysis patients than in healthy subjects. A deficiency of selenium and increased oxidative stress result in significant increases in the incidence of cardiomyopathy. In contrast, supplementation of selenium reduces the risk of cardiomyopathy. We suggest dietary selenium supplementation for prevention of myocardial disorders in hemodialysis patients. |
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