The Japanese Journal of Clinical Dialysis Vol.20 No.9(11)

Theme Trace Elements in Dialysis Treatment
Title New phosphate binder, lanthanum carbonate
Publish Date 2004/08
Author Yoshindo Kawaguchi Kanagawa Prefectural Hospital Affiliated with Nurses Training School / Jikei University School of Medicine
[ Summary ] A new non-calcium, non-aluminum phosphate binder, lanthanum carbonate has been introduced. Up to this time, a number of phosphate binders have been tried experimentally or clinically, but no satisfactory agents have been developed for clinical use, because of their low efficacy or their adverse effects.
Lanthanum carbonate may potentially be a useful and safe phosphate binder for patients undergoing dialysis, however, some issues remain to be solved before worldwide use can begin. These issues include developing accurate and low-cost methods of determining levels of lanthanum in the plasma, tissues and bone, and the also longterm clinical outcomes, especially in relation to adverse phenomena, with continuous exposure to lanthanum.
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