| Theme | Importance of Preservative Management in Chronic Renal Failure -- for a Better Dialysis | |
|---|---|---|
| Title | Long term clinical effects of Kremezin for patients with chronic renal failure | |
| Publish Date | 2004/06 | |
| Author | Kunimi Maeda | Department of Nephrology, Juntendo University, School of Medicine |
| [ Summary ] | Uremic toxins have been defined the courses of uremia. But recently, they are thought to be the substances that have bad influence upon undialyzed chronic renal failure patients, or have closely related to many complications of long termed dialyzed patients. At present, Beta2 microgloburin, AGEs, homocystein and indoxyl sulfate have been considered the important uremic toxins. An oral adsorbent called Kremezin that can remove uremic toxins in the digestive tract and inhibit the progression of renal failure has already been applied clinically in Japan. We analyzed the long term clinical effects of Kremezin on one hundred undialyzed chronic renal failure outpatients from the changes in 1/s-Cr before and after the administration of Kremezin. The results showed that improvements in 1/s-Cr were in proportion to the duration of Kremezin administration and the concentration of serum creatinine (s-Cr). The patients under fifty or over seventy showed better improvements in 1/s-Cr. Chronic glomerulonephritis showed much greater improvements in terms of 1/s-Cr than nephrosclerosis and diabetic nephropathy. In conclusion, we recommend that the oral adsorbent Kremezin should be started when there are lower concentrations of serum creatinine. |
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