| Theme | Biocompatibility on Materials for Dialysis Equipments and Devices | |
|---|---|---|
| Title | The change of radical related markers in several blood purification modalities | |
| Publish Date | 2004/05 | |
| Author | Tadashi Tomo | Second Department of Internal Medicine, Oita Medical University |
| [ Summary ] | We evaluated patients treated with HDF and HD in view of radical stresses encountered in the course of blood purification. Chronic dialysis patients were randomly subjected to four types of blood purification treatment. Determinations were made for radical related markers in relation to: total-pentosidine, free-pentosidine, total-CML, and free-CML. In addition, chemiluminescence was used to observe changes in plasma radicals. Total-CML and total-pentosidine increased when the patients were treated with HD, but decreased significantly in comparison with HDF, they were treated with HDF. Post dilution and pre dilution with HD revealing that the hydroperoxide post/pre-dilution ratio was significantly lower. The reason for the decrease in AGEs in the HDF is considered, first, to be because of the direct removal of CML, pentosidine (radical related markers) through the loss of proteins. The second, consideration was the inhibition of the promotion of CML, pentosidine (radical related markers) with a decrease in radical stress during blood purification by both removal of radical carrier proteins or complement proteins such as factor D, as well as the dilution of plasma with massive substitution of fluids, was observed. |
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