| Theme | Biocompatibility on Materials for Dialysis Equipments and Devices | |
|---|---|---|
| Title | Relationships between inflammatory cytokines and dialysate purity | |
| Publish Date | 2004/05 | |
| Author | Yoshiaki Takemoto | Department of Urology, Osaka City University Graduate School of Medicine |
| Author | Kenji Tsuchida | Department of Urology, Osaka City University Graduate School of Medicine |
| Author | Rikio Yoshimura | Department of Urology, Osaka City University Graduate School of Medicine |
| Author | Tatsuya Nakatani | Department of Urology, Osaka City University Graduate School of Medicine |
| [ Summary ] | Microbiological dialysate contamination was remained relatively ignored in relation to hemodialysis until the 90 ies because there was a strong convinion that these contaminantes could not pass through the dialyser membrane during hemodialysis therapy. Recently, dialysate purity has become the major concern in hemodialysis therapy. The reasons are as follows: first, the use of highly permeable dialyser membranes has enhanced the backfiltration from the dialysate to the blood, which enhances the risks of contaminantion of dialysis fluids. Secondly, it has been shown that bacteria-derived products (endotoxins, peptidoglycans, etc) result in the synthesis and release of proinflammatory cytokines (IL-1, TNF, IL-6, etc) via the activation of monocytes/macrophages during hemodialysis therapy. Thirdly, it has also been reported that dialysis related amyloidosis, such as carpal tunnel syndrome was delayed by the use of ultrapure dialysates. Therefore, ultrapure dialysates should be used all hemodialysis patients in the near future. | |