| Theme | New Turn of Acute Blood Purification | |
|---|---|---|
| Title | Endogenous cannabinoids, ANA and 2-AG were the pathological mediators of acute hemocatharsis therapy | |
| Publish Date | 2004/04 | |
| Author | Tomonori Uchimura | Laboratory and Vascular Medicine, Cardiovascular and Respiratory Disorders, Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Sciences |
| Author | Ikuro Maruyama | Laboratory and Vascular Medicine, Cardiovascular and Respiratory Disorders, Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Sciences |
| [ Summary ] | The existence of exogenous cannabinoid receptors, CB1 and CB2 has been demonstrated. The endogenous agonists of cannabinoid receptors have been identified as the anandamide (ANA) and 2-arachidonoyl glycerol (2-AG). Recently, ANA and 2-AG have been considered to exert, effects on cardiovascular actions, such as being contributors to endotoxin induced hypotension. Direct hemoperfusion (DHF) with an endotoxin adsorbent column, using polymyxin B-immobilized fiber (PMX-F) has been shown to improve the condition of patients with septic shock. Very recently, we demonstrated that polymyxin B absorbs ANA and 2-AG at high affinity rates in vivo and in vitro. These two lipid mediators, ANA and 2-AG were very important substances in therapeutic targeting and the pathogenesis of endotoxin shock. | |