| Theme | Dialysis Amyloidosis -- Present State of the Art | |
|---|---|---|
| Title | Pathologic findings of amyloidosis associated with hemodialysis | |
| Publish Date | 2004/02 | |
| Author | Mitsuru Hara | Department of Pathology, Toranomon Hospital |
| Author | Shigeko Hara | Center of Health Management, Kidney Center, Toranomon Hospital |
| [ Summary ] | In cases showing beta2-microglobulin (beta2-m) amyloid deposition, in a study of autopsy cases of chronic renal failure treated by hemodialysis, the shortest period of hemodialysis was 2 years. The incidence of beta2-m amyloidosis increases as the dialysis period is lengthened. A histologic feature of beta2-m amyloidosis is macrophage infiltration around deposited amyloid, which is thought to be caused by modification of beta2-m amyloid with advanced glycation end products (AGE). Immunohistologically, AGE is positive only in amyloid cases treated by hemodialysis for over 10 years. This means that it takes nearly 8 years for deposited beta2-m amyloid to be modified with AGE. |
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