| Theme | New Development in CAPD Therapy | |
|---|---|---|
| Title | New insights on oxidative stress and peritoneal injury leading to useable antioxidant therapy | |
| Publish Date | 2004/10 | |
| Author | Tamaki Sasaki | Nephrology, Internal Medicine, Kawasaki Medical School |
| Author | Hideyuki Horike | Nephrology, Internal Medicine, Kawasaki Medical School |
| Author | Sohachi Fujimoto | Nephrology, Internal Medicine, Kawasaki Medical School |
| Author | Shinya Kobayashi | Nephrology, Internal Medicine, Kawasaki Medical School |
| Author | Masahito Ozeki | Nephrology, Internal Medicine, Kawasaki Medical School |
| Author | Naoki Kashihara | Nephrology, Internal Medicine, Kawasaki Medical School |
| [ Summary ] | Chronic peritoneal dialysis can result in several peritoneal alterations of varying degree, which lead to progressive reduction in dialytic efficacy. It has been suggested that oxidative stress plays a key role in the pathogenesis of peritoneal injuries. This raises the possibility that antioxidant therapy may be of great interest in these injuries. However, the role of oxidative stress is called into question from the results of intervention studies with antioxidants, which are inconclusive or unsuccessful. New insights into the mechanisms leading to the generation of oxidative stress in CAPD complications are now available. Presumably these findings have led to the discovery and evaluation of new antioxidant molecules, that hopefully may inhibit, at an early stage, the mechanism leading to CAPD complications. While waiting for these specific new compounds, it is reasonable to suggest that readily available substances, such as biocompatible CAPD solutions, should also be used because they are effective antioxidants. | |