| Theme | Diagnostic and Therapeutic Guidelines in End-stage Renal Failure | |
|---|---|---|
| Title | Guidelines for dialysate-producing fluids and dialysate compositions | |
| Publish Date | 2004/01 | |
| Author | Masashi Suzuki | Kidney Center of Shinraku-En Hospital |
| [ Summary ] | Although tap water is regulated by the authorities, it is not always preferable for dialysis treatment, because water regulations are made with healthy populations in mind. Water for dialysate production should be treated carefully to remove harmful substances, such as aluminium, with a reverse-osmosis system or other equivalent methods. A recent concern has been biological purity, especially the level of pyrogens. Pyrogens in the disysate could cause acute or chronic inflammation. Therefor the recommended maximal endotoxin leves in dialysates are 250 to 100IU/l in Japan, 250 to 30IU/l in Europ, and 2,000IU/l in the USA, respectively. Few guidelines are available for the prescribed compositions, except one for pediatric peritoneal dialysis made by a European working group. |
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