| Theme | New Trends in Peritoneal Dialysis Technologies | |
|---|---|---|
| Title | Effect of GDPs on peritoneal resident cells | |
| Publish Date | 2003/05 | |
| Author | Takashi Horiuchi | Department of Life Science and Technology, Faculty of Engineering, University of East Asia |
| Author | Naoko Doi | Department of Life Science and Technology, Faculty of Engineering, Department of Technology, University of East Asia |
| [ Summary ] | D-glucose is a mono-saccharide, used as an osmotic agent in peritoneal dialysis (PD) solutions. In the liquid phase, the closed chain (known as pyranose) is somewhat open, forming a reactive aldehyde group at the C terminal. The stability of this structure is dependent on pH levels. When the pH is weakly acidic, glucose degradation products (GDPs) are produced in lower quantities than when there is a neutral pH. This is the reason why acidic pH levels have been employed in conventional PD solutions. It has become less important to discern whether pH or GDPs has the dominant effect on peritoneal cells. The most crucial issue in the development of PD solutions, using D-glucose, is to minimize harmful GDP constituents as much as possible under neutral pH conditions. |
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