| Theme | Imagination and Evaluation of the Dialysis Dose | |
|---|---|---|
| Title | Dialysis dose in relation to hemodialysis treatment modalities | |
| Publish Date | 2003/09 | |
| Author | Toshiyuki Kanamori | Bio-Nanomaterials Team, Research Center of Advanced Bionics, National Institute of Advanced Industrial Science and Technology |
| [ Summary ] | In this paper, "dialysis dose" is discussed in terms of the removal of uremic toxins. The removal of a uremic toxin for a definite period does not differ with the modalities of hemodialysis (HD) treatment and only time-related changes in the concentration of toxins differ with the modalities used. The time-related changes in concentrations of uremic acid (UA) and beta-2-micoroglobulin (Beta2-m) for patients was maintained by standard and short-time daily HD treatments are discussed using a mathematical kinetic model. TAC (time-averaged concentration) of UA and Beta2-m for the short-time daily HD treatment (2hr/treatment and 6 treatments/week) are lower than those for the standard HD treatment (4 hr/treatment and 3 treatments/week). The effect is to produce a decrease in TAC, which is larger for Beta2-m than for UA. | |