| [ Summary ] |
Renal osteodystrophy (ROD), one of the important complications of end-stage renal disease, is a multifactorial disorder of bone metabolism and remodeling. For quite some time, bone biopsy has been used as the golden standard for investigation of etiology, diagnosing of bone types, and assessing the response to treatment in ROD. The histomorphometric analysis includes three types of measurements performed by double labeling of tetracycline: 1) bone mass parameters, 2) static parameters of bone formation and resorption, and 3) dynamic parameters of bone formation and mineralization. Based on this analysis, patients are classified into 5 different groups (ostitis fibrosa, osteomalacia, and mixed, mild and adynamic forms). In this paper we introduce the methodological procedure for the histomorphometric analysis in bone biopsy, and we present several interesting cases that were diagnosed by bone biopsy. |