| Theme | Intoxication of Drugs and Poisons and Blood Purification Therapy (Case Report) | |
|---|---|---|
| Title | Amantadine hydrochloride intoxication and hemocatharsis | |
| Publish Date | 2002/07 | |
| Author | Toyohiko Nagaya | Laboratory of Clinical Engineering, Gifu-ken Koseiren-Gihoku General Hospital |
| Author | Kazuyoshi Hayakawa | Department of Internal Medicine, Gifu-ken Koseiren-Gihoku General Hospital |
| Author | Yo Yasuda | Department of Internal Medicine, Gifu-ken Koseiren-Gihoku General Hospital |
| [ Summary ] | In our investigation of the literature on the treatment of amantadine intoxication with hemocatharsis, it was reported that in 48 hr peritoneal dialysis decreased the blood drug concentration from 1,500ng/ml to 900ng/ml, and 4 hr hemodialysis showed the rate of elimination to be less than 5% when 300mg/day of amantadine hydrochloride was administered to dialysis patients. It has also been reported that Direct hemoperfusion (DHP) decreased the blood concentration of amantadine from a pre-DHP level of 2,400ng/ml to 1,400ng/ml the next day. In the present case, the rate of adsorption of amantadine was 93.5% 30min after the start of DHP, and it was also confirmed that the rate of removal by Hemofiltration was 21.4% when the replaced fluid volume was 20l. | |