| Theme | Dialysis and Cystic Renal Disease | |
|---|---|---|
| Title | Polycystic kidney vascular disease, brain aneurysms and intracranial bleeding | |
| Publish Date | 2002/05 | |
| Author | Mitsuyuki Fujitsuka | Department of Neurosurgery, Kyorin University, School of Medicine |
| Author | Yoshiaki Shiokawa | Department of Neurosurgery, Kyorin University, School of Medicine |
| Author | Isamu Saito | Department of Neurosurgery, Kyorin University, School of Medicine |
| [ Summary ] | Autosomal dominant polycystic kidney disease (ADPKD) is associated with a variety of cardiovascular abnormalities, including intracranial aneurysms, various other aneurysms and dissection of the aorta, and a number of valvular abnormalities such as mitral, tricuspid conditions, aortic regurgitation, and mitral and tricuspid valve prolapse. In particular, subarachnoid hemorrhage caused by rupture of intracranial aneurysm and intracranial hemorrhage mainly due to hypertension, often lead to serious sequelae and death. Considering the natural history of ADPKD, it is more desirable that prophylactic surgical treatment of non-ruptured cerebral aneurysms before patients suffer overt renal dysfunction. As hypertension is an early and frequent manifestation of ADPKD, detection and control of hypertension is vitally important in patients with ADPKD for prophylaxis against hemorrhagic cerebrovascular events. | |