| Theme | Internal Filtration Enhanced Hemodialysis | |
|---|---|---|
| Title | Performance and clinical evaluation of the internal filtration enhanced dialyzer with high filling factor | |
| Publish Date | 2002/04 | |
| Author | Takeru Shibata | Kidney Center Toranomon Hospital / Clinical Engineer |
| Author | Shigeko Hara | Department of Blood Purification, Toranomon Hospital |
| Author | Nobuhide Mimura | Department of Blood Purification, Toranomon Hospital |
| [ Summary ] | In the area of hemodialysis, hemodiafiltration is easily performed by using an internal filtration enhanced dialyzer. These internal filtration enhanced dialyzers can be categorized as to the type that raises pressure lost in the circulatory system or the type that raises pressure lost in the dialysate system. With either type, reverse filtration of 2.5-3.5L/hr occurs under dialysis conditions in which the dialysis membrane area is about 2.0m2, the blood flow rate is 250mL/min. and there is a dialysate flow rate of 500mL/min, permitting the elimination of beta2-MG equivalent to 10-15L HDF. However, the type that increases pressure in the dialysate system has a problem, in that it causes hypercoagulation with a low blood flow volumes or produces a remarkable decrease in dialysis efficiency with a low dialysate flow volumes. In the future, it will be possible to produce an optimum design for small and high-performance internal filtration enhanced dialyzers with excellent antithrombotic action and operability by maintaining the ratio of hollow fiber filling at about 70% in the dialyzer, and taking into consideration various factors, such as dialysis membrane efficiency, inner diameters and the effective length of hollow fibers. |
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