| Theme | Sleep Apnea Syndrome in Maintenance Hemodialysis Patients | |
|---|---|---|
| Title | Endocrine disorders and sleep apnea syndrome | |
| Publish Date | 2002/02 | |
| Author | Hiroki Sakakibara | Division of Respiratory Medicine and Clinical Allergy, Department of Internal Medicine, Fujita Health University School of Medicine |
| Author | Yasuhiro Uchiyama | Division of Respiratory Medicine and Clinical Allergy, Department of Internal Medicine, Fujita Health University School of Medicine |
| Author | Kazunari Himeno | Division of Respiratory Medicine and Clinical Allergy, Department of Internal Medicine, Fujita Health University School of Medicine |
| [ Summary ] | Endocrine and metabolic physiology is often influenced by behavioral states of sleep and wakefulness. Obstructive sleep apnea cause various types of sleep disturbance, decreased deep sleep, frequent arousals, and abnormal REM-sleep cycle, which may lead to abberations in neuroendocrine and metabolic functions. TNF alpha is a somnogenic factor, and patients with obstructive sleep apnea syndrome may have an elevated plasma TNF alpha level due to chronic sleep disturbance. The elevated TNF alpha level may be a key factor for the development of insulin resistance in patients with obstructive sleep apnea syndrome. Conversely, a certain endocrine disorders, such as hypothyroidism, acromegaly and Cushing's syndrome cause sleep apnea. | |