The Japanese Journal of Clinical Dialysis Vol.18 No.2(2)

Theme Sleep Apnea Syndrome in Maintenance Hemodialysis Patients
Title Pathophysiology and mechanisms of sleep apnea
Publish Date 2002/02
Author Tsuyoshi Nakano Otaru Municipal Hospital
[ Summary ] Sleep apnea is defined as complete cessation of breathing during sleep for more than ten seconds and classified into obstructive, central and mixed types. Sleep apnea syndrome is defined as a potentially lethal condition characterized by multiple obstructive or mixed apneas during sleep associated with repetitive episodes of inordinately loud snoring and excessive daytime sleepiness. A frequently quoted publication defines sleep apnea syndrome as the presence of 30 or more episodes of apnea per 7 hour sleep period or more than 5 episodes per an hour sleep. Obstructive sleep apnea is caused by a discoordination of diaphragm and upper airway muscle control and obesity, while central sleep apnea by absent ventilatory drive and unstable respiratory drive.
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