The Japanese Journal of Clinical Dialysis Vol.18 No.12(2-3-3)

Theme Gastrointestinal Complications in Dialysis Patients
Title Drug-associated colitis
Publish Date 2002/11
Author Kazuya Makiyama Department of Endoscopy, Nagasaki University School of Medicine
[ Summary ] In patients undergoing hemodialysis, excretory functions, endocrine functions, and bodily fluid regulating systems controlling as renal function are impaired. Therefore, drug-related direct/indirect mucosal disorders of the gastrointestinal tract readily occur. When diarrhea, anal bleeding, abdominal pain, and fever are observed in hemodialysis patients, prescribed drugs should be checked, and colonoscopic examination without bowel preparation should be immediately performed. Antibiotic associated colitis (pseudomembranous colitis, hemorrhagic colitis) and NSAIDs-associated colitis are frequently detected. Furthermore, when a cation exchange resin is used to treat hyperpotassemia, it should be considered that this treatment may cause serious injury to the intestinaltract, including ileus, perforation of the large bowel, and necrosis of the large bowel.
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