| Theme | How To Use Monitoring Machines | |
|---|---|---|
| Title | Laser particle monitor for dialysis fluid | |
| Publish Date | 2002/09 | |
| Author | Shigeru Wada | Department of Hemodialysis Section, Osaka Ekisaikai Hospital |
| Author | Tadayuki Maruyama | Department of Hemodialysis Section, Osaka Ekisaikai Hospital |
| Author | Takeshi Wakikawa | Internal Medicine, Osaka Ekisaikai Hospital |
| Author | Akiko Yamada | Internal Medicine, Osaka Ekisaikai Hospital |
| Author | Satoshi Sasaki | Internal Medicine, Osaka Ekisaikai Hospital |
| [ Summary ] | Exclusion of endotoxins (ET) from water for dialysate is important, considering that exposure of dialysis patients to ET leads to fever, hypotension and dialysis-related amyloidosis. However, some reports suggest that insoluble particles in original water or from pipe-line other than those of originating from microorganisms, are contained in the dialysis fluid. These non-physiological substances, similar to ET, also may produce the forementioned reactions in dialysis patients. Although there is disagreement about the evaluation of water used for dialysate ET particle concentration, cannot be detected by the methods used for ET measurements, which specifically measure the concentrations of gram-negative bacillus. A conductivity meter cannot detect the non-charged substance either, though it can detect electrolytes and charged substances. Therefore, we showed the efficacy of laser particle monitoring (MILPA, Mikunikikai, Ltd.), which detects particles larger than 0.1micro-m in the water by using a semiconductor laser. MILPA which could indicate particle values in water for dialysate when it cannot be measured by using ET measurements or a conductivity meter. Furthermore, we revealed the existence of particles in the pure dialysate through an ET cut filter, despite non-detectable ET concentrations. We considered that the purity of dialysis fluid can not be fully evaluated by analyzing only ET concentrations, as generally recommended, and that evaluation of particle values was also important. |
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