| Theme | Adequate Dialysis : Current Topics in Kinetic Modeling | |
|---|---|---|
| Title | The concept and application of compartment model | |
| Publish Date | 2001/04 | |
| Author | Toshiyuki Kanamori | Institute of Materials and Chemical Processes, National Institute of Advanced Industrial Science and Technology |
| [ Summary ] | Assuming that there are one or several homogeneous compartments in the human body, the law of conservation of mass is applied to each compartment. Therefore, mass balance equations for solutes and water are ohtainable for each compartment. The kinetics for solutes and water can be derived as functions of time, with parameters of generation rates for each compartment, mass and water transfer rates between compartments and between compartments and the outside enviroment. This modeling method is known as the "Compartment Model." It is not easy to determine how many compartments we should assume there to be in the human body. Generally, a model with more compartments can represent more complicated phenomena but loses the generality of expression. It is very important to make a suitable model by choosing the essences of those phenomena examined, with reasonable assumptions being made. |
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