| Theme | Adequate Dialysis : Current Topics in Kinetic Modeling | |
|---|---|---|
| Title | Urea kinetics in chronic renal failure patients | |
| Publish Date | 2001/04 | |
| Author | Kenji Maeda | Department of Internal Medicine, Nagoya University Daiko Medical Center |
| Author | Shigeru Nakai | Department of Internal Medicine, Nagoya University Daiko Medical Center |
| Author | Takahiro Shinzato | Department of Internal Medicine, Nagoya University Daiko Medical Center |
| [ Summary ] | Low protein diet therapy is given before dialysis therapy is begun for chronic renal failure patients. Such patients must be monitored to determine whether or not they have the target protein intake. Borah et al., and Maroni et al. have reported methods for calculating the estimated protein intake using a urea kinetic model. Also, in low protein diet therapy, as the energy intake decreases and the protein catabolic rate increases one must prevent a corresponding diminishment of physical strength. The %creatinine generation rate (%CGR) is employed as an index of the muscle mass and exercise amount. A formula has been developed to determine energy intake from the PCR and the %CGR. Since these indicators are calculated on the basis of the urea nitrogen and creatinine in urine stored for 24 hours, the PCR, %CGR and other indices should be computed from urine swtored at less than 1O°C for exactly 24 hours. |
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