| Theme | Adequate Dialysis : Current Topics in Kinetic Modeling | |
|---|---|---|
| Title | Kinetic modeling in apheresis therapies | |
| Publish Date | 2001/04 | |
| Author | Kei Eguchi | Division of Blood Purification, Kidney Center, Tokyo Women's Medical University |
| Author | Ryo Yokoi | Division of Blood Purification, Kidney Center, Tokyo Women's Medical University |
| Author | Iwakazu Kaneko | Division of Blood Purification, Kidney Center, Tokyo Women's Medical University |
| Author | Masaaki Kimikawa | Department of Surgery, Kidney Center, Tokyo Women's Medical University |
| Author | Michio Mineshima | Division of Blood Purification, Kidney Center, Tokyo Women's Medical University |
| Author | Takashi Akiba | Division of Blood Purification, Kidney Center, Tokyo Women's Medical University |
| Author | Hiroshi Nihei | Department of Medicine, Kidney Center, Tokyo Women's Medical University |
| [ Summary ] | In several types of aphereis therapy, the patient's blood volume often decreases over time during treatment, due to a drop in colloidal osmolarity. This is induced by blood dilution from the aqueous solution primer in the device before the treatment and albumin loss from treatment, especially in the partially discarded mode of the double filtration plasmapheresis. Kinetic modeling for albumin transport during DFPP treatment was introduced to explain changes in blood volume during treatment, in order to determine the optimal concentration of substitution fluid for treatment. | |