| Theme | Management of Systemic Diseases with Blood Purification : Aute and Chronic Stage of Diseases | |
|---|---|---|
| Title | Endocrine disease (thyrotoxic crisis etc.) | |
| Publish Date | 2001/03 | |
| Author | Yoshihiro Tominaga | Department of Sugery Renal Center and Blood Purification Center, Nagoya 2nd Red Cross Hospital |
| [ Summary ] | A thyrotoxic crisis is defined as a state of severe thyrotoxicosis with a high mortality rate, if adequate diagnosis and treatment can not be performed. Since turnover of thyroxin is low, it is difficult to rapidly suppress the synthesis of thyroxin and to reduce the serum level of the hormone with medication. Plasma pheresis is indicated for patients in very severe states, such as comma, severe heart failure, or shock, to rapidly remove both intravascular and extravasucular thyroxin. It has heen speculated that Grave's ophthalmopathy is induced by immunoreaction of auto-antibodies such as TSH receptor antibodies:TRAb, thyroid stimulating antibodies: TSAb and/or, thyroid stimulating blocking antibodies TSBAb, against the tissue surrounding the eye, in which same antigens existing in thyroid tissue are expressed. Plasma pheresis can remove theses auto-antibodies and is indicated for patients with severe ophthalmopathy. It has heen reported that plasma pheresis is clinically useful. |
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