| Theme | Management of Cardio-vascular Complication in Hemodialysis Patient | |
|---|---|---|
| Title | Arteriosclerosis and disorder of lipid metabolism | |
| Publish Date | 2001/09 | |
| Author | Keigo Kimura | Third Department of Internal Medicine, Wakayama Medical College |
| Author | Masatoshi Mune | Third Department of Internal Medicine, Wakayama Medical College |
| [ Summary ] | There are cardio-vascular complications for hemodialysis patients, which are due to arteriosclerosis. This is the number one cause of death for dialysis patients. We measured the calcification of an abdominal aorta, using CT scanning, to produce a calcification index. From this, we produced an arteriosclerosis index. For examinations, using multiple regression analysis for non-diabetes mellitus dialysis patients, there were one hundred and three cases, in which we examined factors, including age, systolic blood pressure, serum calcium, phosphorus by products, and serum Lp(a), which were considered to be statistically significant. The most characteristic change in the serum lipid levels of hemodialysis patients is a prevalence of high triglyceride blood disease and low HDL cholesterol blood disease. Serum Lp(a) is also found in high levels. It is important that disorders, related to lipid metabolism are seen as risk factors for arteriosclerosis, causing heart and vascular complications, which are major complications for hemodialysis patients. These complications must be improved, especially since it has become clear that they are important in the care of hemodialysis patients, with complications, such as hypertension or diabetes mellitus. Presently available antihyperlipidemic medications, as well as dialyzers and related treatments, including anticoagulants, in which calcium-phosphorus dysbolism is a particular factor, must be improved, in order to treat disorders of lipid metabolism in hemodialysis patients. It is necessary to carry out examinations, in terms of quantitative abnormalities of lipids, but also in terms of the connection with the progress of arteriosclerosis and increases in levels of LDL. In the future, consideration must be given to disorders of lipid metabolism in hemodialysis patient. |
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