| Theme | Forefront of Diabetic Nephropathy | |
|---|---|---|
| Title | Polyneuropathy associated with diabetic or nondiabetic uremic patients | |
| Publish Date | 2001/01 | |
| Author | Takashi Hasegawa | Department of Nephrology, National Higashi-utsunomiya Hospital |
| Author | Naoyuki Osaka | Division of Nephrology and Hypertension, Jikei University School of Medicine |
| Author | Hiroko Toshima | Department of Health and Environmental Medicine, Jikei University School of Medicine |
| Author | Tatsuo Hosoya | Division of Nephrology and Hypertension, Jikei University School of Medicine |
| Author | Yoshindo Kawaguchi | Kanangawa Prefectural Hospital Affilited with Nurses Traning School |
| [ Summary ] | Diabetic or uremic polyneuropathy is a symmetrical, distal, mixed motor and sensory polyneuropathy that affects the legs more than the arms. The first symptom for most patients with these neuropathies is dysensthesias of the lower distal extremities, which progressively spreads. We studied peripheral nerve conduction velocities in patients with end-stage renal failure, as well as hemodialised patients. Measurements were compared for nondiabetic uremic patients and two categorized groups of type 2 diabetic-uremic patients according to their serum HbA1c Motor nerve conduction velocity of median and peroneal nerves, and sensory nerve conduction velocity of sural nerves significantly decreased in the higher HbA1c diabetic group, less so than in the nondiabetic group (p<O.O5). Our results suggest that poorly contorolled diabetic uremic patients have more severe polyneuropathies than nondiabetic uremic patients. |
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