| Theme | Risk Factors and Outcome on Long-term Dialysis | |
|---|---|---|
| Title | Risk factors on renal osteodystrophy and metastatic calcification in patients with long-term dialysis | |
| Publish Date | 2000/06 | |
| Author | Satoshi Kurihara | Division of Nephrology, Kasukabe-Shuwa Hospital |
| Author | Masaru Suga | Division of Nephrology, Kasukabe-Shuwa Hospital |
| [ Summary ] | In dialysis patients, various types of renal osteodystrophy (ROD) and metastatic calcifications frequently develop because of abnormalities in parathyroid hormone (PTH) levels, aluminum accumulation, metabolism of calcium (Ca), phosphate (P) and vitamin D, and many other processes. Bone and joint pain are frequently seen in patients with ROD, and pathological fractures are also often noticed. These conditions affect the quality of life and worsen the prognosis for dialysis patients. Aplastic bone disease (ABD), a group of disorders now increasing in prevalence, is characterized by abnormal Ca homeostasis, with increased risk of calcification in the cardiovas cular system. It has also been shown that patients with low serum PTH levels have higher mortality rates than patients with adequate PTH levels. To prevent ABD and extraosseous calcifications in dialysis patients, suitable serum Ca, P and PTH levels should be maintained through proper preparation of phosphate binders, vitamin D derivatives, and Ca concentrations in the dialysate. |
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