| [ Summary ] |
Several types of dialyzers, with enhanced internal filtration, have been introduced for clinical applications. In these dialyzers, enhanced internal filtration increased convective transport of the solute, in addition to diffusive transport. Internal filtration is strongly affected by the effective length (Leff), inner diameter (D), and density ratio (FDR) of the hollow fibers. As a result of analytical study, the flow rate of internal filtration (QIF) was increased, resulting in a smaller D, a longer Leff, and a larger FDR value. Solute clearance, especially in larger molecular weight solutes, was increased with the QIF value. Development of a dialyzer with enhanced internal filtration, however, should take the patient's safety into account. Hemolysis and endotoxin invasion from the dialysate to the patient should be avoided. |