| Theme | Apheresis | |
|---|---|---|
| Title | Virus inactivation / removal in apheresis | |
| Publish Date | 1999/06 | |
| Author | Hideki Abe | Hokkaido Red Cross Blood Center |
| Author | Sadami Sekiguchi | Hokkaido Red Cross Blood Center |
| [ Summary ] | Photosensitization can inactivate several viruses in blood products. Methylene blue, methylene blue derivatives, psoralen derivatives, and phthalocyanine derivatives are used for treatment of plasma, platelets red cells or as a photosensitizer. Only the methylene blue photoinactivation meyhods is clinically used for plasma products, but others are in the experimental stages. Leukocyte-associated virus transmission can be prevented by leukocyte-removal filters. Viruses in blood plasma products can be removed by using microporous-hollow fiber membrane. |
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