| Theme | Strategy for the Treatment of Chronic Renal Failure in Children | |
|---|---|---|
| Title | Treatment by renal transplantation -- Present status of renal transplantation in children | |
| Publish Date | 1999/04 | |
| Author | Akira Hasegawa | Department of Nephrology, Toho University School of Medicine |
| [ Summary ] | The 1996 annual report of the North American Pediatric Renal Transplant Cooperative Study(NAPRTCS)summerized data voluntarily collected from 130 centers on 4,329 pediatric and adolescent patients who recieved renal transplants on or after January 1, 1987, The registry shows pre-emptive transplantations were performed on 24% of the patients. In out 47% of 4,715 pediatric renal transplant cases, parents or other living relatives were donors. The median time to the first rejection was 46 days for cadaver donor (CD) transplants and 377 days for living donor (LD) grafts. Five-year graft survival rates were 73.4% for LD grafts and 56.4% for CD grafts. Since 1991, no cadaver donors have been less than 2 years old. The percentage of cadaver donors aged over 10 years old increased from 68% to 88%. Zero matches in HLA-DR locus occurred in 45.7% of the entire CD transplant group, and zero matches in either the B or DR locus occurred in 31% of CD grafts. More than 5 units of preoperative random blood transfusion jeopardized graft outcome. |
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