| Theme | Strategy for the Treatment of Chronic Renal Failure in Children | |
|---|---|---|
| Title | Trial for the delay of the progression in chronic renal failure -- Diet therapy, ACEI and renal adsorbent | |
| Publish Date | 1999/04 | |
| Author | Yoshiyuki Yoshida | Yoshida Children's Clinic |
| [ Summary ] | As a test of the ability to delay the of progression of chronic renal failure (CRF), we have been performing therapy to promote the inhibition of some factors in the progression of glomerular sclerosis. These factors are glomerular hypertension, glomerular hypertrophy, epithelial damage, increase in the mesangial matrix and uremic toxins. In addition to the limitation of NaCl, related to hypertension, low protein diet therapy is one of the most important treatments for CRF. It is necessary to maintain compliance in order to preserve adequate patient energy levels. Angiotensin II converting enzyme inhibitor is useful for the patients with CRF and hypertension, and patients with FGS with glomerular hypertrophy. Careful observation of renal function is important. In addition to low protein diet therapy, oral adsorbents for uremic toxins are required produce inhibitory effects in the progression of CRF, even in its early stages. |
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