| Theme | Homocysteinemia in Association with Chronic Renal Failure | |
|---|---|---|
| Title | Hyperhomocysteinemia and cerebral infarction | |
| Publish Date | 1999/02 | |
| Author | Hiromichi Kumagai | University of Shizuoka, School of Food and Nutritional Sciences |
| Author | Kazutoshi Sugimoto | Department of Clinical Nutrition, Hagoromo-no-sono |
| Author | Shuzo Kobayashi | National Defence Medical College, Second Department of Medicine |
| [ Summary ] | The number of cerebral infarctions has been increasing in dialysis patients, and the incidence of lacunar infarctions diagnosed by MRI has been reported to be much higher in patients with chronic renal failure than in the normal population. Recently, hyperhomocysteinemia has been recognized as an important risk factor for the cerebral infarction. We investigated the relationship between lacunar infarction and plasma total homocysteine concentrations (tHcy) in 41 patients with chronic renal failure,who have not received dialysis therapy. The incidence of lacunar infarction was 17% in the low tHcy group(plasma tHcy<12 micro mol/l), 39% in the middle tHcy group (12-22 micro mol/l) and 64% in the high tHcy group (>22 micro mol/l).There were no differences in other vascular risk factors in these groups. These data indicated that hyperhomocysteinemia was a serious risk factor for lacunar infarction in chronic renal failure. | |