| Theme | Multiple Organ Failure and Blood Purification Therapy | |
|---|---|---|
| Title | Pathophysiology and diagnosis of multiple organ disfunction syndrome | |
| Publish Date | 1999/09 | |
| Author | Shigeatsu Endo | Critical Care and Emergency Center, Iwate Medical University |
| Author | Shigeru Taniguchi | Critical Care and Emergency Center, Iwate Medical University |
| Author | Katsuya Inada | Department of Bacteriology, Iwate Medical University |
| Author | Takae Kawamura | Department of Anesthesiology, Iwate Medical University |
| Author | Nobuhiro Sato | Department of Surgery, Iwate Medical University |
| [ Summary ] | The systemic inflammatory response is seen in association with various clinical conditions. Tumor necrosis factor, or other cytokines play an important role in systemic inflammatory response syndrome (SIRS). A frequent complication of SIRS is the development of organ system dysfunction, such as ARDS, DIC, renal failure, shock, and multiple organ dysfunction. Inflammatory cytokines become a trigger for the production of phospholipase A2, eicosanoids, NO, endothelin-1, thrombomodulin, polymorphonuclear leukocyte, and adhesion molecules. These mediators cause complex pathophysiologic condition in SIRS. | |