| Theme | Progress and Future in Blood Purification | |
|---|---|---|
| Title | History of changes glucose concentration and bases in hemodialysate | |
| Publish Date | 1999/01 | |
| Author | Kiyoshi Ozawa | Department of Nephrology, Hiratsuka Kyosai Hospital |
| [ Summary ] | In the early days of dialysis, water removal depended on the osmotic gradient generated by unphysiologically high concentration of dialysate glucose. This was because the dialyzer membrane had a low UFR and could not tolerate high TMP. Development of good membranes decreased dialysate glucose concentrations to physiological levels of, 100 to 150 mg/dl. Acetate is stable and sterile in dialysate and metabolized to base in the body This factor played a major role in the population explosion of HD patients. But too great an acetate load caused various untoward effects. Nowadays bicarbonate has taken the place of acetate. |
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