| Theme | Pathophysiology and Treatment of Deranged Lipid Metabolism in Chronic Renal Failure | |
|---|---|---|
| Title | Effects of dialyzer, dialysate and anticoagulant on lipid metabolism in hemodialysis patients | |
| Publish Date | 1998/09 | |
| Author | Yoshinobu Ohtsubo | Wataru Yamashita Clinic |
| Author | Kenichi Takenouchi | The 2nd Department of Internal Medicine, Kagoshima University |
| Author | Syouzou Takenouchi | The 2nd Department of Internal Medicine, Kagoshima University |
| [ Summary ] | It is well-known that dialysate and heparin, used for hemodialysis treatment have important effects on lipid metabolism in hemodialysis patients. Some recent data, including ours, has shown that some kinds of membranes, such as polysulfone, cellulose triacetate and polyamide have beneficial effects on lipid abnormalities in hemodialysis patients. In our study cellulose triacetate and polysulfone membranes absorbed Apo CIII in the form of lipid-free apolipoprotein. The beneficial effects of these membranes may be due to the membrane material regardless of its cut-off point. The influence of dialysate and anticoagulants on lipid metabolism, in hemodialysis patients may help explain why serum HDL-C concentrations are higher in patients taking bicarbonate than in those on acetate hemodialysis, and why serum triglyceride levels decreased when patients received hemodialysis using heparin, which has a low molecular weight. Hemodialysis conditions such as dialyzers, dialysates and anticoagulants may have an important influence on lipid metabolism in hemodialysis patients. |
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