| Theme | Blood Purification Solution | |
|---|---|---|
| Title | Neutralized CAPD fluid | |
| Publish Date | 1998/08 | |
| Author | Tadashi Yamamoto | Department of Medical Technology, Shirasagi Hospital |
| Author | Masao Kim | Department of Surgery, Shirasagi Hospital |
| [ Summary ] | Dialysate pH is an important factor in improving biocompatibility. Cultured rabbit mesothelial cells exposed to dialysate at neutralized pH levels demonstrated good viability, though exposure to dialysate at low pH decreased their viability. As for the clinical use of neutralized dialysate, a sensation of fullness in the abdomen was decreased and the need for ultrafiltration was increased. Concentrations of IL-6 in the effluent were increased when low pH dialysate was substituted for neutralized dialysate. A pH level over 6.5 is most suitable for the neutralized dialysate, but a pH level of 5.8 is also possible if the titratable acid from the dialysate is low. |
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