| Theme | Blood Pressure Control in Chronic Renal Failure | |
|---|---|---|
| Title | Mechanism of blood pressure increase and choice of antihypertensive agents for CAPD patients | |
| Publish Date | 1997/09 | |
| Author | Noriaki Yorioka | 2nd Department of Internal Medicine, Hiroshima University School of Medicine |
| Author | Takao Masaki | 2nd Department of Internal Medicine, Hiroshima University School of Medicine |
| [ Summary ] | Important mechanisms underlying an increase of blood pressure in patients on CAPD include fluid retention and stimulation of the renin-angiotensin system. Other possible mechanisms are increased sympathetic nervous activity, a decrease of hypotensive substances, an increased intracellular calcium level, and an increase of vasoconstrictor substances. Recombinant human erythropoietin is used in the treatment of renal anemia and it can also increase blood pressure. Hypertension is first treated by control of the fluid balance, and calcium antagonists and ACE inhibitors are the antihypertensive agents of first choice. | |