| Theme | Hypoparathyroidism and Related Problems in Dialysis Patients | |
|---|---|---|
| Title | Synthesis, secretion and metabolism of parathyroid hormone | |
| Publish Date | 1997/01 | |
| Author | Seiji Fukumoto | 4th Department of Internal Medicine, The University of Tokyo School of Medicine |
| Author | Toshio Matsumoto | 4th Department of Internal Medicine, The University of Tokyo School of Medicine |
| [ Summary ] | Parathyroid hormone (PTH) plays a pivotal role in the maintenance of the extracellular calcium (Ca) concentration. The most important factor regulating the secretion of PTH is the concentration of extracellular ionized Ca. This ion increases the intracellular Ca concentration of parathyroid cells through its action on parathyroid Ca-sensing receptor and inhibits the secretion of PTH. In addition, there are nucleotide sequences in the upstream region of the PTH gene that respond to Ca or 1,25-dihydroxyvitamin D and inhibit the synthesis of the PTH. The metabolism of synthesized PTH in parathyroid cells may also be regulated by Ca. Elucidating the mechanisms of the inhibition of PTH secretion by increased intracellular Ca and the inhibitory effects of Ca and 1,25-dihydroxyvitamin D on PTH transcription would allow the development of new ways to treat parathyroid diseases. | |