| Theme | Depressed type colorectal cancer -- Revolution and since then | |
|---|---|---|
| Title | Current status, significance and issues of IIctype colorectal cancer in each field: Significance of pericryptal fibroblast and phenotypic expression in tumor development | |
| Publish Date | 2021/12 | |
| Author | Takashi Yao | Department of Human Pathology, Juntendo University Graduate School of Medicine |
| [ Summary ] | About 30 years have passed since the author's introduction to pathology has led to the discovery of many colorectal IIc-type cancer. To date, we have analyzed the characteristics of non-polypoid growth (NPG)-and polypoid growth (PG)-type tumors and observed that NPG-type tumors (which are highly malignant lesions) play an important role in the development of colorectal cancer. However, the elucidation of its essence is still insufficient. Notably, IIc-type lesions are diagnostically challenging, show rapid progression, and are highly malignant; therefore, prompt detection during the early stage when they are likely to be amenable to endoscopic curative resection is important. It is necessary to review IIc lesions to gain a deeper understanding of this type of malignancy with a new feeling. | |