| Theme | Colorectal cancer screening and surveillance -- Prospects towards standardization from new findings | |
|---|---|---|
| Title | Risk stratification of screened individuals in colorectal cancer screening | |
| Publish Date | 2021/05 | |
| Author | Masau Sekiguchi | Cancer Screening Center, National Cancer Center Hospital / Division of Screening Technology, Center for Public Health Sciences, National Cancer Center / Endoscopy Division, National Cancer Center Hospital |
| Author | Takahisa Matsuda | Cancer Screening Center, National Cancer Center Hospital / Division of Screening Technology, Center for Public Health Sciences, National Cancer Center / Endoscopy Division, National Cancer Center Hospital |
| [ Summary ] | In colorectal cancer (CRC) screening, risk stratification of screened individuals is essential for efficient utilization of colonoscopy. The fecal immunochemical test (FIT) plays a key role as a risk stratification tool in many countries, including Japan. However, the screen sensitivity of a single FIT for advanced colorectal neoplasia is low, and other noninvasive methods are warranted for risk stratification inCRC screening. In such cases, the combined use of risk stratification score comprising of the screened individuals' baseline characteristics and FIT resultscould be helpful. A recent study showed that the combined use of the 8-point risk score, which could be useful inscreened Japanese individuals, and the FIT yielded higher screen sensitivity for advanced colorectal neoplasia, particularly for right-sided advanced colorectal neoplasia, than FIT alone. Further assessment and discussion of this combined use should be conducted for CRC screening. | |