| Theme | Current destination of "de novo cancer" | |
|---|---|---|
| Title | Positioning of de novo cancer judging from growth progress | |
| Publish Date | 2020/04 | |
| Author | Akihiro Ouchi | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Division of Endoscopy, Kurume University School of Medicine |
| Author | Osamu Tsuruta | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Division of Endoscopy, Kurume University School of Medicine |
| Author | Yoshio Kusaba | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Division of Endoscopy, Kurume University School of Medicine |
| Author | Tsutomu Nagata | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Division of Endoscopy, Kurume University School of Medicine |
| Author | Tomonori Cho | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Division of Endoscopy, Kurume University School of Medicine |
| Author | Tomoyuki Nakane | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Division of Endoscopy, Kurume University School of Medicine |
| Author | Shuhei Fukunaga | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Division of Endoscopy, Kurume University School of Medicine |
| Author | Michita Mukasa | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Division of Endoscopy, Kurume University School of Medicine |
| Author | Keiichi Mitsuyama | Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine / Division of Endoscopy, Kurume University School of Medicine |
| [ Summary ] | There are four theories for colon carcinogenesis: 1) adenoma-carcinoma sequence, 2) de novo cancer theory, 3) serrated polyp neoplasia pathway, and 4) colitic cancer. In the adenoma-carcinoma sequence, all colorectal carcinomas arise from benign adenomas, while in de novo cancer theory, most colorectal carcinomas arise from normal colonic mucosa, not from adenomas. The adenoma-carcinoma sequence is generally accepted globally. However, many flat and depressed early colorectal carcinomas have been detected in Japan and have no concomitant adenoma component. Hence, these types of carcinomas are thought to be de novo. Nonetheless, the present problems include the difference in pathological diagnosis standard of adenoma and cancer among pathologists, pathomorphological considerations, and the diagnosis of de novo cancer being impossible. | |