| Theme | Endocrine cell tumors of the colorectum: Difference in concept between WHO classification and Japanese classification | |
|---|---|---|
| Title | Diagnosis and treatment of goblet cell carcinoids of the appendix | |
| Publish Date | 2019/02 | |
| Author | Seiji Shimizu | Division of Gastroenterology and Hepatology, Osaka General Hospital of JR West Railway Company |
| Author | Kiyoshi Ogiso | Division of Gastroenterology and Hepatology, Osaka General Hospital of JR West Railway Company |
| Author | Hideo Tomioka | Division of Gastroenterology and Hepatology, Osaka General Hospital of JR West Railway Company |
| Author | Kyohei Ikeda | Division of Gastroenterology and Hepatology, Osaka General Hospital of JR West Railway Company |
| Author | Hirokazu Uejima | Division of Gastroenterology and Hepatology, Osaka General Hospital of JR West Railway Company |
| Author | Chihiro Yokomizo | Division of Gastroenterology and Hepatology, Osaka General Hospital of JR West Railway Company |
| Author | Hidetaka Takashima | Division of Gastroenterology and Hepatology, Osaka General Hospital of JR West Railway Company |
| [ Summary ] | Goblet cell carcinoids are rare tumors mostly originating from the appendix. Since lymph node metastasis and/or peritoneal dissemination often accompany, it is considered to be a variant of carcinoma. Tumor cells have a tendency to spread in the submucosa and deeper layers without exposure to the mucosal surface. The major reason for operations is acute abdomen, followed by appendiceal tumors and intestinal obstruction. Diagnosis is rarely established before surgery, and is usually made by postoperative histology. As CT findings, swelling of the appendix and thickening of ileoceacal wall with contrast enhancement are described. Colonoscopy and/or barium enema X-rays are infrequently used. Findings may include masses or irregularities in the appendiceal orifice and strictures or deformities in the cecum. However, endoscopic findings may be normal. Histological diagnosis of biopsy specimens is often unsuccessful. Principally surgical resection is performed. However, chemotherapy for colorectal cancer is used in advanced cases. | |