| Theme | Molecular biology of colorectal tumors | |
|---|---|---|
| Title | Molecular abnormalities of hereditary/familial gastrointestinal tumors | |
| Publish Date | 2018/09 | |
| Author | Kazuo Tamura | Laboratory of Molecular Biology, Department of Life Science, Faculty of Science and Engineering, Kinki University |
| [ Summary ] | Most hereditary gastrointestinal tumors are associated with autosomal dominant inheritance. Therefore, one in two off spring of the proband have a risk of these tumors. Each responsible gene has been isolated, and genetic testing has become possible with the integrated understanding of the disorders. Using genetic testing for presymptomatic diagnosis enables an early diagnosis, thus leading to progress in anti-cancer measures. As hereditary heterogeneity exists for these diseases, genetic testing becomes useful for a differential diagnosis with other related diseases. When the characteristics and specialties of hereditary/familial gastrointestinal tumors syndrome and their responsible genes are sufficiently understood, genetic testing should be utilized for the improvement of cancer medicine. | |